- Provides your body with bio-active phytonutrients necessary to produce Sulforaphane
- Boost your cell’s natural defense mechanism against toxins and pollutants for up to 72 HOURS by delivering:
- Detoxification – Up-regulates your body’s detoxification enzymes
- Antioxidation – Stimulates production of other antioxidant in your body
- Anti-Inflammation – Inhibit pro-inflammatory signalling
- Optimises your cellular health
- Anti Cancer
- Induces cancer cell death (apoptosis)
- Inhibit cancer cell angiogenesis (new blood vessels forming)
- Inhibit cell cycle progression (reduce cancer cell replication)
2 reasons – Safety and Efficacy
How can you be sure it works?
The difference lies in our proprietary patented process to preserve the bioactive compounds (i.e. enzyme active). Studies have shown the importance of enzyme (active) Myrosinase, to convert Glucoraphanin to Sulforaphane. Bioavailability of sulforaphane is dramatically lower when the enzyme Myrosinase is not active.
Therefore, you should be wary of other products marketed as containing broccoli sprout, broccoli sprout extract, or seed extract which claim to contain sulforaphane glucosinolate. These could in fact only contain the precursor glucoraphanin and none of the essential bio-active myrosinase enzyme.
How can you be sure it’s safe for you and your loved ones?
It is fully grown in Australia, in a specialised, controlled environment FREE from any pesticides or other harmful chemicals. We do not add any additives, filler, preservatives, flavouring, colour, etc. ActiCell is a 100% pure whole food powder, nothing else added!
Serving size: 2 grams or approximately 1 teaspoon.
Serving suggestion: Mix into water, other beverage or sprinkled on food (room temperature or cold only), once or twice daily. To ensure bioactivity, consume within 30 minutes of mixing.
Ingredients: (ActiCell) enzyme active broccoli sprout powder.
Storage: Store below 30C away from light and moisture. Best to keep refrigerated after opening.
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- Gamet-Payrastre, Laurence, et al. “Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells.” Cancer research 60.5 (2000): 1426-1433.
- Juge, N., R. F. Mithen, and M. Traka. “Molecular basis for chemoprevention by sulforaphane: a comprehensive review.” Cellular and Molecular Life Sciences 64.9 (2007): 1105-1127.
- Myzak, Melinda C., et al. “A novel mechanism of chemoprotection by sulforaphane inhibition of histone deacetylase.” Cancer Research 64.16 (2004): 5767-5774.
- Clarke, John D., Roderick H. Dashwood, and Emily Ho. “Multi-targeted prevention of cancer by sulforaphane.” Cancer letters 269.2 (2008): 291-304.
- Chiao, J. W., et al. “Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells.” International journal of oncology 20.3 (2002): 631-636.
- Li, Yanyan, et al. “Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells.” Clinical Cancer Research 16.9 (2010): 2580-2590.
- Fimognari, Carmela, et al. “Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane.“Carcinogenesis 23.4 (2002): 581-586.
- Yeh, Chi-Tai, and Gow-Chin Yen. “Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells.“Carcinogenesis 26.12 (2005): 2138-2148.
- Keum, Young‐Sam. “Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications.” Annals of the New York Academy of Sciences 1229.1 (2011): 184-189.
- Fimognari, Carmela, and Patrizia Hrelia. “Sulforaphane as a promising molecule for fighting cancer.” Mutation Research/Reviews in Mutation Research 635.2 (2007): 90-104.
- Yeh, Chi-Tai, and Gow-Chin Yen. “Chemopreventive functions of sulforaphane: A potent inducer of antioxidant enzymes and apoptosis.“Journal of Functional Foods 1.1 (2009): 23-32.
- Cheung, Ka Lung, and Ah-Ng Kong. “Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention.” The AAPS journal 12.1 (2010): 87-97.
- Gamet-Payrastre, L. “Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis.” Current cancer drug targets 6.2 (2006): 135-145./li>
- Morimitsu, Yasujiro, et al. “A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway.” Journal of Biological Chemistry277.5 (2002): 3456-3463..
- Vauzour, David, et al. “Sulforaphane protects cortical neurons against 5‐S‐cysteinyl‐dopamine‐induced toxicity through the activation of ERK1/2, Nrf‐2 and the upregulation of detoxification enzymes.” Molecular nutrition & food research 54.4 (2010): 532-542.
- Misiewicz, Irena, et al. “Sulforaphane-mediated induction of a phase 2 detoxifying enzyme NAD (P) H: quinone reductase and apoptosis in human lymphoblastoid cells.” ACTA BIOCHIMICA POLONICA-ENGLISH EDITION-(2004): 711-722.
- Gao, Shang Shang, et al. “Sulforaphane induces glutathione S‐transferase isozymes which detoxify aflatoxin B1‐8, 9‐epoxide in AML 12 cells.“BioFactors 36.4 (2010): 289-296.
- Angeloni, Cristina, et al. “Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential.” Journal of agricultural and food chemistry 57.12 (2009): 5615-5622.
- Ritz, Stacey A., Junxiang Wan, and David Diaz-Sanchez. “Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract.” American Journal of Physiology-Lung Cellular and Molecular Physiology 292.1 (2007): L33-L39.
- Ye, Lingxiang, and Yuesheng Zhang. “Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes.“Carcinogenesis 22.12 (2001): 1987-1992.
Antioxidation - Oxidative Stress, Free Radicals, etc
- Guerrero-Beltrán, Carlos Enrique, et al. “Protective effect of sulforaphane against oxidative stress: recent advances.” Experimental and Toxicologic Pathology 64.5 (2012): 503-508.
Keum, Young-Sam, et al. “Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element–mediated heme oxygenase-1 in human hepatoma hepG2 cells.” Cancer research 66.17 (2006): 8804-8813.
Zhu, Hong, et al. “Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress.” Cardiovascular toxicology 8.3 (2008): 115-125.
- Paolini, Moreno, et al. “Induction of cytochrome P450, generation of oxidative stress and in vitro cell-transforming and DNA-damaging activities by glucoraphanin, the bioprecursor of the chemopreventive agent sulforaphane found in broccoli.” Carcinogenesis 25.1 (2004): 61-67.
- Danilov, Camelia A., et al. “Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation.” Glia 57.6 (2009): 645-656.
- Greco, Tiffany, Jonathan Shafer, and Gary Fiskum. “Sulforaphane inhibits mitochondrial permeability transition and oxidative stress.” Free Radical Biology and Medicine 51.12 (2011): 2164-2171.
- Hybertson, Brooks M., et al. “Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation.” Molecular aspects of medicine 32.4 (2011): 234-246.
- Heiss, Elke, et al. “Nuclear factor κB is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.” Journal of Biological Chemistry276.34 (2001): 32008-32015.
Brandenburg, Lars-Ove, et al. “Sulforaphane suppresses LPS-induced inflammation in primary rat microglia.” Inflammation Research 59.6 (2010): 443-450.
Cheung, Ka Lung, Tin Oo Khor, and Ah-Ng Kong. “Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation.” Pharmaceutical research 26.1 (2009): 224-231.
- Saw, Constance L., et al. “Impact of Nrf2 on UVB‐induced skin inflammation/photoprotection and photoprotective effect of sulforaphane.“Molecular carcinogenesis 50.6 (2011): 479-486.
- Guerrero-Beltrán, Carlos Enrique, et al. “Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy.” The Journal of nutritional biochemistry 23.5 (2012): 494-500.